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Ambitions for theory in the physics of life

by William Bialek

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Submission summary

Authors (as registered SciPost users): William Bialek
Submission information
Preprint Link: https://arxiv.org/abs/2401.15538v2  (pdf)
Date accepted: 2024-06-25
Date submitted: 2024-04-11 16:12
Submitted by: Bialek, William
Submitted to: SciPost Physics Lecture Notes
 for consideration in Collection:
Ontological classification
Academic field: Physics
Specialties:
  • Biophysics
Approach: Theoretical

Abstract

Theoretical physicists have been fascinated by the phenomena of life for more than a century. As we engage with more realistic descriptions of living systems, however, things get complicated. After reviewing different reactions to this complexity, I explore the optimization of information flow as a potentially general theoretical principle. The primary example is a genetic network guiding development of the fly embryo, but each idea also is illustrated by examples from neural systems. In each case, optimization makes detailed, largely parameter-free predictions that connect quantitatively with experiment

Published as SciPost Phys. Lect. Notes 84 (2024)


Reports on this Submission

Report #3 by Anonymous (Referee 1) on 2024-6-11 (Invited Report)

  • Cite as: Anonymous, Report on arXiv:2401.15538v2, delivered 2024-06-11, doi: 10.21468/SciPost.Report.9229

Strengths

1. Very thorough review of the work done in the past 15 years on precision in fly development and 30 years in vision, as illustrations of progress made at the intersection of physics and biology.
2. Deep mathematical details that will allow students to understand the full derivations.
3. Broad view that allows the reader to grasp many different model systems at once under a unifying framework.
4. Very pedagogical and engaging.

Weaknesses

The paper has no apparent weakness.

Report

I recommend publication without changes.

Recommendation

Publish (surpasses expectations and criteria for this Journal; among top 10%)

  • validity: -
  • significance: -
  • originality: -
  • clarity: -
  • formatting: -
  • grammar: -

Report #2 by Anonymous (Referee 2) on 2024-4-11 (Invited Report)

  • Cite as: Anonymous, Report on arXiv:2401.15538v2, delivered 2024-04-11, doi: 10.21468/SciPost.Report.8867

Strengths

These notes succeed in building a tool set and a base of intuition about
what optimization principles to look for in biology and where. They
lucidly guide the reader on how to apply such principles in practice;
tightly weaving together pedagogical problems and examples from
cutting-edge research. Entry points to a broad corpus of literature are
provided throughout.

Report

Acceptance criteria are met.

Recommendation

Publish (surpasses expectations and criteria for this Journal; among top 10%)

  • validity: -
  • significance: -
  • originality: -
  • clarity: -
  • formatting: -
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Report #1 by Anonymous (Referee 3) on 2024-4-11 (Invited Report)

Strengths

A very interesting set of notes written for physics and biology students based on lectures presented at the Les Houches summer school.

Report

Yes

Recommendation

Publish (surpasses expectations and criteria for this Journal; among top 10%)

  • validity: -
  • significance: -
  • originality: -
  • clarity: -
  • formatting: -
  • grammar: -

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