Ambitions for theory in the physics of life
William Bialek
SciPost Phys. Lect. Notes 84 (2024) · published 15 August 2024
Part of the 2023-07: Theoretical Biological Physics 2023 Collection in the Les Houches Summer School Lecture Notes Series.
- doi: 10.21468/SciPostPhysLectNotes.84
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Abstract
Theoretical physicists have been fascinated by the phenomena of life for more than a century. As we engage with more realistic descriptions of living systems, however, things get complicated. After reviewing different reactions to this complexity, I explore the optimization of information flow as a potentially general theoretical principle. The primary example is a genetic network guiding development of the fly embryo, but each idea also is illustrated by examples from neural systems. In each case, optimization makes detailed, largely parameter-free predictions that connect quantitatively with experiment.